Microneedles based drug delivery systems: an updated review

A review of the microneedles for transdermal drug delivery

Microneedles consist of micron-sized projections similar to needles. They are capable of piercing through the stratum corneum and increase the permeation of active ingredients. Besides active pharmaceutical ingredients, microneedles can also deliver cosmetic agents, biotherapeutics like insulin and vaccines and also are used in diagnostic purposes. This article examines the types of microneedle...

Nanoscale drug delivery systems: An updated view

Microneedles for Ocular Drug Delivery

Statement of Purpose: Targeted drug delivery into the eye is a challenging task because of a variety of barriers that prevent safe and effective delivery. Topical application to the eye is hindered by low residence time resulting in poor diffusion of drug into intraocular tissues. Intravitreal injection can deliver drugs to the retina effectively but is invasive and carries risk of infection. I...

Microneedles for transdermal drug delivery.

The success of transdermal drug delivery has been severely limited by the inability of most drugs to enter the skin at therapeutically useful rates. Recently, the use of micron-scale needles in increasing skin permeability has been proposed and shown to dramatically increase transdermal delivery, especially for macromolecules. Using the tools of the microelectronics industry, microneedles have ...

Ocular Drug Delivery Using Microneedles

To my dearest parents For their love, trust and supports ACKNOWLEGMENT I would like to thank my advisor, my thesis committee members, my research colleagues, my family and my friends who made this thesis possible. I would like to thank my thesis advisor, Mark Prausnitz for his support during my thesis work. Without his guidance, it would be difficult for me to complete my study. I would like to...